Synonyms: Tritolyl Phosphate; Phosphoric Acid Tris(Methylphenyl)Ester; TCP
CAS No.: 1330-78-5
Molecular Weight: 368.37
Chemical Formula: (CH3C6H4O)3PO
Product Codes: W601
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Phosphoric Acid, 1330-78-5 90 - 100% Yes tris(methylphenyl)ester
Emergency Overview
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WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 2 - Moderate (Life)
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 2 - Moderate (Life)
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Green (General Storage)
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Potential Health Effects
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Tricresyl Phosphate (TCP) exists in three isomeric forms: ortho, meta, and para. The commercial product is a mixture of the three forms with as little of the highly toxic ortho-isomer (TOCP) as possible. The meta- and para-isomers are relatively inactive. The human lethal oral dose of TOCP is about 1 g/kg; doses of 6 to 7 mg/kg have produced serious paralysis.
Inhalation:
Since TCP has low volatility, vapor inhalation is unlikely at normal temperatures; however, it may be a hazard if boiled. Mist or vapor can cause irritation to respiratory tract. May be absorbed into the bloodstream with symptoms similar to ingestion.
Ingestion:
Causes irritation to the gastrointestinal tract. Symptoms may include nausea, vomiting and diarrhea. Breathing or swallowing large quantities may cause neurological disturbances which may progress to delayed neurotoxicity characterized by ataxia and tremors.
Skin Contact:
Causes irritation to skin. Symptoms include redness, itching, and pain. May be absorbed through the skin without local irritant effects; symptoms similar to ingestion.
Eye Contact:
Causes irritation, redness, and pain. Rapid eye oscillation with dizziness may occur.
Chronic Exposure:
Repeated exposure may cause symptoms similar to those listed for acute effects. TCP inhibits cholinesterase. Neurologic damage can be severe and permanent.
Aggravation of Pre-existing Conditions:
No information found.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Note to Physician:
Consider gastric lavage if patients are comatose or at risk of convulsing. Since prolonged diarrhea may occur, avoid cathartic administration. Avoid administration of atropine and 2-PAM chloride (protopam) since these agents are ineffective. Chronic poisoning: treat for polyneuritis. Experimental cholinesterase reactivators used for therapeutic use in TCP poisoning show encouraging results. Observe all exposures for delayed peripheral neuropathies, particularly the axonal type.
Fire:
Flash point: 410C (770F) CC
Fire Hazard when exposed to heat or flame. However, the high flash point reduces its fire hazard, and it tends to stop burning when the ignition source is removed.
Explosion:
Not considered to be an explosion hazard.
Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water may be ineffective. Water spray may be used to keep fire exposed containers cool. Do not allow water runoff to enter sewers or waterways.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer!
Keep in a tightly closed galvanized steel container, stored in a cool, dry, ventilated area away from direct sunlight and open flames. Protect against physical damage. Isolate from any source of heat or ignition. Containers should be effectively sealed and clearly marked. Tricresyl phosphates should not be used in plastic articles which are likely to come into contact with foodstuffs or clothing. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product.
Airborne Exposure Limits:
For Tricresyl Phosphate (TCP):
- None Established
For Triorthocresyl Phosphate (TOCP):
- OSHA Permissible Exposure Limit (PEL) -
0.1 mg/m3 (TWA).
- ACGIH Threshold Limit Value (TLV) -
0.1 mg/m3 (TWA) skin, A4 - not classifiable as a human carcinogen.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible, a half facepiece particulate respirator (NIOSH type N95 or better filters) may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest.. A full-face piece particulate respirator (NIOSH type N100 filters) may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Appearance:
Colorless to pale yellow, oily liquid.
Odor:
Odorless.
Solubility:
Insoluble in water.
Specific Gravity:
1.16-1.175 @ 20C
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
241 - 255C (466 - 491F) At 4 mm Hg.
Melting Point:
< -40C (< -40F)
Vapor Density (Air=1):
12.7
Vapor Pressure (mm Hg):
Not applicable.
Evaporation Rate (BuAc=1):
Not applicable.
Stability:
Stable under ordinary conditions of use and storage. Hydrolyzes slowly at room temperature under wet alkaline conditions.
Hazardous Decomposition Products:
Phosphorus oxides may form when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Tricresyl phosphate can react with oxidizing materials, especially when heated. TCP is inert to common metals.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.
For Tricresyl Phosphate (TCP): 3 gm/kg oral rat LD50; irritation data - skin mild (open Draize, 500 mg, rabbit), and eye mild (std Draize, 500 mg/24H, rabbit). Investigated as a tumorigen and a reproductive effector.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Phosphoric Acid, No No None
tris(methylphenyl)ester (1330-78-5)
Environmental Fate:
When released into the soil, this material is expected to readily biodegrade. When released into the soil, this material is not expected to leach into groundwater. When released into the air, this material may be moderately degraded by reaction with photochemically produced hydroxyl radicals.
Environmental Toxicity:
This material is expected to be very toxic to aquatic life. The LC50/96-hour values for fish are less than 1 mg/l.
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
Domestic (Land, D.O.T.)
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Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (CONTAINS TRICRESYL PHOSPHATE WITH <1% ORTHO ISOMER)
Hazard Class: 9
UN/NA: UN3082
Packing Group: III
Information reported for product/size: 4L
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (CONTAINS TRICRESYL PHOSPHATE WITH <1% ORTHO ISOMER)
Hazard Class: 9
UN/NA: UN3082
Packing Group: III
Information reported for product/size: 4L
International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (CONTAINS TRICRESYL PHOSPHATE WITH <1% ORTHO ISOMER)
Hazard Class: 9
UN/NA: UN3082
Packing Group: III
Information reported for product/size: 4L
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Phosphoric Acid, tris(methylphenyl)ester Yes Yes Yes Yes
(1330-78-5)
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Phosphoric Acid, tris(methylphenyl)ester Yes Yes No Yes
(1330-78-5)
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Phosphoric Acid, tris(methylphenyl)ester No No No No
(1330-78-5)
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Phosphoric Acid, No No No
tris(methylphenyl)ester (1330-78-5)
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Liquid)
Australian Hazchem Code: None allocated
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
NFPA Ratings: Health: 2 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS.
Label Precautions:
Avoid contact with eyes, skin and clothing.
Wash thoroughly after handling.
Avoid breathing vapor or mist.
Keep container closed.
Use only with adequate ventilation.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. In all cases, get medical attention.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 3.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)